In this paper, rheological experiments are carried out on natural hornblende under high temperature and high pressure. We used polarizing microscope and scanning electron microscope to analyze the experimental samples' microstructure, investigating the mechanisms of hornblende under the condition of different temperature, pressure and strain rate. The experimental results reveal the following features of the stress-strain curves of deformed samples: As the temperature increases, the stress-strain curve of the samples changes gradually from strengthening to yielding and weakening, sample strength reduces significantly; with the increase of confining pressure, the sample strength increases; and with the decrease of strain rate, the sample strength reduces, and it significantly reduces in the samples with the compression direction heterotropic to foliation. Plenty of transgranular fractures as well as a small amount of cataclastic deformation occur in hornblendite at temperature of 500℃, and the deformed sample is dominated by brittle deformation. At temperature of 600℃, porphyroclast system consisting of residual plaques and cataclastic series grows in the samples, wavy extinction appears in part of hornblende crystals, the deformation is characterized mainly by cataclastic deformation with ductile deformation, locally. At temperature of 700℃, the deformation is mainly dominated by intragranular kink, and dehydration and fine-grained microcrystalline appear locally, containing microcracks. The deformation of the sample is in the brittle-plastic transition phase; At temperature of 800℃, almost no obvious brittle deformation is observed in the deformed samples, the samples are dominated by dynamic recrystallization, and dehydration appears. Therefore, at the temperature conditions of 500℃, 600℃, 700℃ and 800℃, the deformation of hornblende is characterized by brittle fracture, cataclastic flow, crystal kink, dynamic recrystallization and dehydration, which shows the deformation mechanism varying from brittle to brittle-ductile, and to ductile deformation.