Tancheng-Lujiang Fault runs through Shandong,Jiangsu,Anhui Provinces of East China,and this segment is called the Shandong-Jiangsu-Anhui segment of the Tancheng-Lujiang fault zone in the paper.By comparative analysis on the data of seismogeology,deep seismic exploration,seismic tomography,seismic activity,geomorphology,crustal motion velocity field and deformation observation,etc.,and based on the principles of historical earthquake recurrence and structure analogy,the possibility is discussed of the occurrence of strong earthquake in the Shandong-Jiangsu-Anhui segment.It is found by comparison between the Wangji-Jiashan region of south Sihong County and epicenter area of the 1668 Tancheng M 81/2 earhtquake that there are high similarities between these two regions in terms of deep-seated and shallow geologic structure,neotectonic movement,and seismic activity,etc.According to the studies of historic seismic event recurrence and tectonic comparison,the area along Wangji to Jiashan of Sihong County along the Shandong-Jiangsu-Anhui segment of the Tancheng-Lujiang fault zone is likely to generate M7 or above strong earthquake.